Unclassified cells that can transform into any mature cell type

What are stem cells?

Stem Cells

These are the building blocks of  regenerative medicine

Stem cell transplantation (SCT) is a medical procedure in which stem cells reconstruct and replace damaged tissues and organs – a potential cure for a wide range of diseases and disorders

Stem cells are extremely difficult to isolate from mature cells

 They are very rare in a human body and "look" the same as any other cell, literally changing their "shape and form" according to the environment

Mature Cell

Stem Cell

In regenerative medicine, while transplanted stem cells can rebuild -

mature donor cells can cause severe damage

Introducing mature cells into any foreign body evokes severe immune reaction (an actual rejection of the transplant) ,severe  morbidity and even death

The most common risk is the

Graft versus Host disease -

Rejection of the recipient tissues and organs by the transplanted stem cells

Graft versus Host disease (GvHD) is a common complication of allogeneic (non-related donor) as well as haploidentical (family member donor) stem cell transplantations

Current transplantations require preventive  treatments

and even then

~50% of the patients

will need chemotherapy and or antibiotics and recurrent hospitalization

The key challenge is

to isolate stem cells from mature cells

In reality, stem cells are not "Blue".

If stem cells could be isolated they could be used for a wide range of regenerative medicine applications and treatments literally regenerating damaged tissues and organs

Mature Cell

Stem Cell

Cellect's ApoGraft is a breakthrough technology isolating stem cells through Apoptosis

Apoptosis

(Ancient Greek ἀπόπτωσις)

Programmed Cell Suicide

"...If cells are no longer needed, they commit suicide by activating an intracellular death program. This process is therefore called programmed cell death, although it is more commonly called Apoptosis (from a Greek word meaning “falling off,” as leaves from a tree)..." - NCBI

A cell given a command to commit suicide

Cellect's key finding is that

in an apoptotic environment, mature cells die while stem cells survive and even flourish

Mature cells die

Stem cells survive

Apoptosis Command is given to all cells

Cellect promotes lacing various containers (such as infusion bags, test tubes etc.) with an apoptosis  inducing protein...

... and within hours from infusing cells  into the container, a safe, effective and non-toxic mass of mostly enriched  stem cells remain

Cellect's technology enables true transformation of the world into the 21st century regenerative medicine

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